Cheap blood pressure med could help treat alcoholism

Studies suggest it may reduce both alcohol cravings and consumption.

A medication used to treat high blood pressure might also be able to help people overcome alcohol use disorder, according to a new study by researchers at the NIH and Yale University.

The challenge: If a person is unable to break drinking habits that are damaging their health, job, or social life, their doctor might diagnose them with alcohol use disorder.

An estimated 14.1 million adults in the US struggle with alcohol use disorder, and while there are multiple types of therapy and three FDA-approved medications for treating the disorder, they don’t work for everyone.

“People with substance use disorders deserve to have a range of treatment options available to them.”

Nora Volkow

The idea: Past research has shown that mineralocorticoid receptors — proteins that help the body regulate blood pressure — may also play a role in alcoholism, with higher receptor activity linked to stronger alcohol cravings.

This prompted researchers at NIDA and NIAAA to wonder if the cheap blood pressure medication spironolactone, which blocks the activity of mineralocorticoid receptors, could effectively treat alcohol use disorder.

The study: To find out, the researchers administered spironolactone to mouse models of alcohol drinking and rat models of alcohol dependence

The drug reduced binge drinking in the mice without causing movement or coordination problems or affecting their water and food intake. Rats treated with the medication, meanwhile, self-administered less alcohol. 

“This study is an exciting step in our effort to expand medications for people with alcohol use disorder.”

Nora Volkow

In a parallel study, researchers at Yale University looked at health records from the US Veterans Affairs healthcare system and discovered a significant association between patients being prescribed spironolactone and a self-reported decrease in alcohol consumption.

The drug appeared to have the biggest impact on people who initially reported hazardous or heavy episodic alcohol consumption.

Looking ahead: The results of animal studies often don’t translate to people, and while the Yale study found an association between spironolactone and decreased alcohol consumption, that doesn’t mean the med caused the decrease.

Clinical trials are still needed to determine whether spironolactone could be an effective treatment for alcohol use disorder, but if so, it could be a cheap, safe way to help millions of people overcome their problems with alcohol.

“Just like for any other medical condition, people with substance use disorders deserve to have a range of treatment options available to them, and this study is an exciting step in our effort to expand medications for people with alcohol use disorder,” said NIDA Director Nora Volkow.

We’d love to hear from you! If you have a comment about this article or if you have a tip for a future Freethink story, please email us at [email protected].

Tooth decay: Mouthwash turns your teeth blue when it’s time to go to the dentist
A mouthwash solution containing ferumoxytol and a dye could treat, prevent, and diagnose tooth decay, according to UPenn researchers.
Brain implant lets cancer patients try 20 different drugs at a time
A microdevice that injects up to 20 drugs into gliomas at once could help doctors quickly identify the best treatment for cancer patients.
A magnetic therapy for depression gains precision
Approved over a decade ago, transcranial magnetic stimulation (TMS) could be effective if the treatment was tailored to individual brains.
Drug for MS may be able to treat Alzheimer’s, too
A drug approved to treat multiple sclerosis reduced neuroinflammation and improved memory in mouse models of Alzheimer’s.
Popular weight-loss drugs show promise as addiction treatments
New trials will test the ability of GLP-1 agonists, a popular class of weight-loss drugs, to help people beat addictions to drugs and alcohol.
Up Next
Subscribe to Freethink for more great stories