Artificial penis tissue restores erections in injured pigs

It might one day help millions of people overcome erectile dysfunction.

Artificial penis tissue developed in China was able to restore erections in pigs with penis injuries — and it could one day do the same for millions of people with Peyronie’s disease, a common and painful cause of erectile dysfunction.

The challenge: During an erection, wavy fibers of a tissue in the penis, called the “tunica albuginea” (TA), straighten and stiffen to help the penis remain firm.

An estimated 10% of people with penises in the US have Peyronie’s disease, a condition in which scar tissue forms in the TA due to either injury or an autoimmune disease. This causes a curve in the penis, and it can make maintaining an erection difficult or painful.

The tissues used to patch the tunica albuginea don’t always perfectly replicate its function.

There is no cure for Peyronie’s disease, and it rarely goes away on its own. To treat people with severe cases, surgeons can remove the scar tissue and replace it with tissue sourced from a tissue donor, an animal, or another part of the patient’s own body.

These biological tissue patches can prevent shortening of the penis following surgery, but they are also sometimes rejected by the immune system, and because they aren’t the exact same structure as natural TA, the transplanted tissues don’t always perfectly replicate its function.

Artificial penis tissue: Researchers at the South China University of Technology have now developed an artificial penis tissue they say matches the biomechanical properties of natural TA better than the biological tissues currently used as patches.

“Our research is based on a simple scientific hypothesis: by simulating the microstructure of natural tissues, we can obtain artificial materials with properties similar to those of the tissues,” senior author Xuetao Shi told Gizmodo.

The results: After determining in the lab that the artificial penis tissue — made from a polyvinyl alcohol hydrogel — should be safe in the body, the researchers used it to repair TA injuries in the penises of pigs bred for medical research.

A month later, the animals showed no signs of rejection. When saline was injected into the patched porcine penises to prompt an erection, the organs became stiff and straight, just like they would have prior to the injury.

Looking ahead: More research is needed before the artificial penis tissue will be ready for testing in humans, but if it works as hoped, it could be a better alternative to the biological tissues currently in use.

Still, TA damage isn’t the only cause of erectile dysfunction, and the Chinese scientists hope future research will allow them to find ways to address problems with other parts of the organ — or even figure out how to construct artificial penises from scratch.

We’d love to hear from you! If you have a comment about this article or if you have a tip for a future Freethink story, please email us at [email protected].

Your microbiome is influenced by the people you hang out with
The human microbiome is largely influenced by our social interactions, according to the largest study to date of microbiome transmission.
mRNA could train our blood cells to stop chronic inflammation
A new study has identified the substance used by our white blood cells to reduce inflammation when it is no longer needed.
Jupiter’s hot “pizza moon” may contain life
Jupiter’s moon Io is thought to be inhospitable, but new data suggests life could exist underground, perhaps in lava tubes.
New study finds 5-minute hack to balance sitting all day at work
Researchers set out to find the least amount of walking one could do to offset the harmful health effects of sitting.
5 biotech trends to watch in 2023
After a monumental year of breakthroughs, scientists, investors, and CEOs share which areas of biotech they are eagerly watching this year.
Up Next
congenital heart defects
Subscribe to Freethink for more great stories