Trial of opioid vaccine launches in US

The shot is designed to prevent the high that can lead to addiction.

An opioid vaccine designed to prevent oxycodone users from feeling “high” is moving from animal trials to humans. If it works as hoped, the shot could help people overcome addiction — and even avoid overdosing if they do relapse.

Opioid use disorder: Opioids are incredibly effective pain relievers, so doctors will often prescribe medications based on them, such as oxycodone and codeine, to people who’ve just had surgery or experienced a serious injury.

However, opioids also produce feelings of euphoria that can lead to misuse — people might take more of the meds than they’re prescribed, purchase them illegally, or use street opioids, such as heroin.

Five times more people died of opioid-related overdoses in 2019 than in 1999.

If they start using the drugs compulsively and in ways that negatively affect their ability to work or lead an otherwise “normal” life, they can be diagnosed with opioid use disorder

A national crisis: In 2019, an estimated 1.6 million Americans were living with opioid use disorder. That same year, more than 70,000 died of opioid-related overdoses — that’s a five-fold increase over the number who died in 1999.

It is possible to treat opioid use disorder with medications, such as methadone, but about half of the people who take them relapse after six months, according to Sandra Comer, a professor of neurobiology at Columbia University.

Now, Comer is leading a trial to test an opioid vaccine that could help people overcome their dependence on oxycodone, one of the most commonly abused prescription opioids.

The opioid vaccine: This vaccine, OXY-KLH, is designed to trigger the production of antibodies that latch on to oxycodone. That prevents the drug from reaching the brain, where it causes the high many addicts crave, as well as the potentially deadly respiratory depression that comes from overdosing.

“A vaccine … could help many more people beat their addiction.”

Sandra Comer

The newly announced human trial will test the shot’s safety, tolerability, and ability to produce the desired antibodies. The researchers also hope to find out if the opioid vaccine can prevent the feeling of euphoria in participants given oxycodone after vaccination.

“A vaccine that lasts for several months, given in combination with any of these [treatment] medications, could help many more people beat their addiction and potentially protect them from an overdose death if a patient relapses,” Comer said.

A focused intervention: The opioid vaccine appears to work in mice — treated animals chose to self-administer oxycodone less often and appeared protected from respiratory distress and other signs of toxicity — but that doesn’t mean it’ll work in humans.

The antibodies only work on oxycodone specifically, meaning it wouldn’t help people addicted to heroin, codeine, morphine, or other opioids. 

However, that focus could be a blessing — if a vaccinated person needed an opioid to treat pain, their doctor could prescribe one of the other meds. Plus, if the shot works as hoped, ones targeting other opioids could follow — heroin and fentanyl vaccines are already in development.

“Clinicians would be able to give the oxycodone vaccine to individuals who mainly use that particular drug but could also administer additional opioid vaccines for those who use other opioids or to prevent patients from switching to another opioid,” Comer said.

We’d love to hear from you! If you have a comment about this article or if you have a tip for a future Freethink story, please email us at

Magic mushrooms evolved to scramble insect brains, send them on wild, scary trips 
Researchers discovered that the way fungi independently gained the ability to produce psilocybin is because of horizontal gene transfer.
New drug combo is “a paradigm shift” in preventing asthma attacks
The combination of a rescue medication and a corticosteroid, taken as needed, reduced both short and long-term risk of asthma attacks.
How we treat inflammation may be causing chronic pain
Reversing common belief, researchers at McGill say treating inflammation may be causing chronic pain, not preventing it.
‘Mad honey’: The rare hallucinogen from the mountains of Nepal 
On the mountainsides of Nepal and Turkey, bees sometimes produce a strange and dangerous concoction: mad honey.
AI maps psychedelic “trip” experiences to regions of the brain – opening new route to psychiatric treatments 
To better understand how these effects manifest in the brain, we analyzed over 6,000 written testimonials of hallucinogenic experiences.
Up Next
dendritic spines
Subscribe to Freethink for more great stories