Weight-loss drug reduces cravings for opioids in small study
A first-of-its-kind trial found that GLP-1 agonists, a popular kind of weight-loss drug, could help people overcome their opioid cravings.
The untapped potential of stem cells in menstrual blood
Stem cells found in menstrual blood could unlock new therapies and diagnostic tests, some researchers argue.
Evidence that gamma rhythm stimulation can treat neurological disorders is emerging
Researchers survey the therapeutic potential of noninvasive sensory, electrical, or magnetic stimulation of gamma brain rhythms.
New pharma supergroup aims to tackle skin disorders
Six biotech companies just merged to form Alys Pharmaceuticals with the goal of developing new treatments for skin disorders.
How to stop our immune systems from turning on us
From "inverse vaccines" to repurposed cancer therapies, several potential cures for autoimmune diseases are showing serious promise.
New hope for early pancreatic cancer intervention via AI-based risk prediction
To train their machine learning models, MIT researchers used electronic health record data from various institutions across the U.S.
One-shot CRISPR treatment for inherited disease aces first human trial
A CRISPR treatment for hereditary angioedema significantly reduced swelling attacks in its first human trial.
New non-opioid pain reliever moves closer to approval
Vertex Pharmaceuticals’ new painkiller, VX-548, significantly reduced moderate-to-severe pain in two phase 3 trials.
Inhalable sensors could enable early lung cancer detection
MIT engineers have designed diagnostic particles that can be aerosolized and inhaled to find cancer-associated proteins in the lungs.
Anti-aging pill for senior dogs is now in clinical trials
An anti-aging pill for senior dogs now in clinical trials might lead to treatments that extend human lives, too.
New antiviral shortens COVID-19 by 1.5 days
People taking simnotrelvir, a new antiviral treatment for COVID-19, felt almost immediate symptom relief and got better 1.5 days faster.
A dietician explains “Zepbound,” the newest weightloss drug
Zepbound recently joined the list of obesity-fighting drugs administered as injections that has been approved by the FDA.
One-and-done anti-aging treatment “rejuvenates” old mice
CAR-T cells that have been modified to target senescent cells could be a one-and-done anti-aging treatment.
Drinking this foam could boost an experimental cancer therapy
A drinkable foam packed with carbon monoxide molecules appears to boost the cancer-killing effects of autophagy inhibitors.
Deaf boy hears within days of receiving new gene therapy
A gene therapy designed to treat a rare form of genetic deafness has restored hearing in the first patient to receive it.
DeepMind’s AI could accelerate drug discovery
A new study suggests that AlphaFold, DeepMind’s AI tool for predicting protein structures, could be useful for drug discovery after all.
Pig liver filters blood outside a person’s body for 72 hours
A gene-edited pig liver that filtered the blood of a person who was brain dead for 72 hours could one day help people with liver failure.
Urine-propelled nanobots shrink bladder tumors by 90% in animals
Tiny, radioactive nanobots propelled by urine shrank bladder tumors by 90% in mice, suggesting a new way to target the disease.
Ultrasound waves help Alzheimer’s drug get into the brain
Beaming focused ultrasound waves into the heads of Alzheimer’s patients helped a drug bypass the blood-brain barrier.
Engineers develop a vibrating, ingestible capsule that might help treat obesity
MIT engineers designed an ingestible capsule that vibrates within the stomach, creating an illusory sense of fullness and reducing appetite.
Are anxiety and depression social problems or chemical disorders?
As antidepressants will soon be a $16B industry, the chemical imbalance theory suits business interests better than health interests.
Using AI, MIT researchers identify a new class of antibiotic candidates
Using a type of artificial intelligence, MIT researchers have discovered a class of compounds that can kill drug-resistant bacteria.
Psychoactive drug ibogaine helps veterans with TBI
A small study found that one dose of ibogaine could reduce the symptoms of a traumatic brain injury (TBI) for military vets.
How a mutation in microglia elevates Alzheimer’s risk
A study finds that microglia with mutant TREM2 protein reduce brain circuit connections, promote inflammation, and contribute to Alzheimer’s.
Superbug-killing antibiotic is now in human trials
A promising new antibiotic that kills a superbug resistant to nearly all available drugs is now being tested in people.
Nutrition professor answers: Does chicken soup really help when you’re sick?
Is chicken soup just a comforting placebo, providing psychological benefit while we’re sick, without an actual therapeutic effect?
Moderna’s mRNA cancer vaccine works even better than thought
Adding Moderna’s mRNA cancer vaccine to a standard melanoma treatment dramatically reduces the risk of death or recurrence.
The 5 most exciting clinical trial results of 2023
In 2023, several potentially game-changing meds, including ones to treat pain and high cholesterol, showed huge promise in human trials.
Chemobrain is real. Here’s what to expect after cancer treatment.
Chemobrain, or chemofog, can significantly affect cancer survivors' quality of life with its social, psychological, and economic impacts.
Experimental implant could end the need for insulin injections
An arm implant containing islet cells could one day make it far easier for people with type 1 diabetes to manage their disease.
Researchers engineer insulin-releasing cells that respond to sound waves
New research in mice attempts to eventually replace insulin injections with the sounds waves of rock music.
This startup is solving the biggest problem to creating drugs that work
Lab-grown human tissues could revolutionize drug development. This AI-powered robot can create and test 10,000 of them at once.
Study: chronic pain’s root cause could be a process in the brain
Understanding that chronic back pain originates from within the brain could lead to quicker recovery, a new study finds.
Bad sleep worsens pain. Researchers may have discovered why.
Inadequate sleep worsens pain, which makes it difficult to sleep. This cycle may stem from disruptions to the body's endocannabinoid system.
Lidocaine makes cancer cells self-destruct, study finds
Lidocaine, a common local anesthetic, activates proteins that cause certain types of cancer cells to self-destruct.
Stem cell injections could be the key to curing MS
From promising stem cell therapies to EBV vaccines, researchers are closer than ever to finding a cure for MS.
Cholesterol drug suggests new way to treat Alzheimer’s
A cholesterol drug that reduced brain damage in mice could reveal a new approach to treating Alzheimer’s disease in people.
First anti-aging drug for dogs nears approval
The FDA is a major step closer to approving biotech company Loyal's LOY-001, the first anti-aging drug for dogs.
Australia’s 30-year quest to unlock an ancient painkiller
A crocodile attack led to a 30-year partnership to develop a painkiller based on the Nyikina Mangala people's traditional knowledge.
Experimental drug cuts heart disease risk factor by 96%
Eli Lilly’s experimental drug lepodisiran reduced blood levels of lipoprotein(a) by up to 96% in a small trial.
Human brains have a remarkable ability to rewire themselves following injury
Every brain injury is unique, as is every person’s path to recovery. A concussion specialist explains the science behind rehabilitation and recovery.
World’s first CRISPR therapy approved in UK
UK regulators have authorized CRISPR Therapeutics’ Casgevy, making it the world’s first approved CRISPR therapy.
Wegovy slashes heart attack risk by 28%
Novo Nordisk’s weight-loss drug Wegovy can reduce a person’s risk of a serious cardiovascular event by 20%.
New gene therapy reverses hearing loss in 4 children
A new gene therapy being trialed in China was able to reverse hearing loss in 4 of the 5 children to receive it.
New “super melanin” protects and heals skin
A “super-charged” synthetic melanin is even better at protecting the skin and healing damage than the natural kind.
Gold-laced gel could help you recover from a major muscle injury
A combination of electrical stimulation and a gold nanoparticle-laced hydrogel could one day help people recover from major muscle injuries.
Blocking this one protein could strengthen muscles
Stanford researchers have figured out how a therapy that blocks a single protein can reverse age-related muscle loss in mice.
CRISPR cure for HIV now tested in 3 people
Excision BioTherapeutics has shared data from the first human clinical trial of a CRISPR cure for HIV. Here's what we know — and don't know.
“Living pharmacies” could mean you never forget to take your meds again
The US government is funding the development of "living pharmacies," implants containing cells that release medications on demand.
“Hydrogel” drugs could suppress HIV with minimal treatments
An injectable solution that self-assembles into a hydrogel to deliver 6 weeks of anti-ARV drugs could make managing HIV less of a burden.
What the science really says about vitamin D deficiency
When is low vitamin D a potential concern? And when might you need to get your levels tested? Here's what the evidence says.
New “Lattice” device tests drugs on eight organs at once
Northwestern University scientists have developed a device that simulates up to eight organs at once to aid drug development.
Is iron the Achilles’ heel for cancer?
Some cancer cells store high quantities of iron. Iron-activated cancer drugs selectively disrupt cancer cells, without harming healthy cells.
Octopus tentacle-like patch delivers drugs through your cheek
A needle-free drug delivery system inspired by octopus tentacles could one day replace injections for administering biopharmaceuticals.
New “multipronged” gene therapy reverses paralysis in mice
A new gene therapy that guides nerve regeneration across complete spinal cord injuries restored the ability to walk in paralyzed mice.
An implantable device could enable injection-free control of diabetes
MIT engineers designed an implantable device that carries islet cells along with its own on-board oxygen factory to keep the cells healthy.
New “inverse vaccines” could be key to curing autoimmune disorders
"Inverse vaccines" that teach the immune system to tolerate triggering molecules could be the key to curing autoimmune disorders.
Tooth decay: Mouthwash turns your teeth blue when it’s time to go to the dentist
A mouthwash solution containing ferumoxytol and a dye could treat, prevent, and diagnose tooth decay, according to UPenn researchers.
Brain implant lets cancer patients try 20 different drugs at a time
A microdevice that injects up to 20 drugs into gliomas at once could help doctors quickly identify the best treatment for cancer patients.
A magnetic therapy for depression gains precision
Approved over a decade ago, transcranial magnetic stimulation (TMS) could be effective if the treatment was tailored to individual brains.
Drug for MS may be able to treat Alzheimer’s, too
A drug approved to treat multiple sclerosis reduced neuroinflammation and improved memory in mouse models of Alzheimer’s.
Popular weight-loss drugs show promise as addiction treatments
New trials will test the ability of GLP-1 agonists, a popular class of weight-loss drugs, to help people beat addictions to drugs and alcohol.
Australian ant honey inhibits tough pathogens, new research shows
Honeypot ant honey may help develop our arsenal of effective antibacterial and antifungal treatments, which are increasingly vital.
At least 5 people have been cured of HIV. Is the AIDS pandemic ending?
A handful of people have already been functionally cured of HIV — and new, universal cures are just on the horizon.
New treatment slashes obesity in mice eating fatty, sugary diet
A new obesity treatment developed at UMass triggered weight loss in mice even as they continued to eat a diet high in fat and sugar.
Transplants of lab-grown brain cells reduce Parkinson’s symptoms
Transplants of lab-grown dopamine neurons reduced the amount of time people experienced Parkinson’s symptoms in a small trial.
Artificial kidney aces test in pigs
An artificial kidney prototype just aced a pig trial, bringing it closer to human trials — and a step closer to ending the need for dialysis.
Potential heart attack treatment discovered in human placentas
Placental cells known to home in on and repair damaged heart cells in mice have been discovered in humans, too.
To stave off Alzheimer’s, protect your brain’s mitochondria
Mitochondria are crucial for memory preservation and are emerging as key players in the fight against Alzheimer's.
World-first experiment shows genetically engineered bacteria detecting cancer
Genetically engineered bacteria could be used to detect a range of different diseases, particularly infections and cancers.
Weight-loss drug improves heart failure symptoms, too
Novo Nordisk’s popular weight-loss drug semaglutide (Wegovy) improved heart failure symptoms in a trial of more than 500 people.
New obesity treatments could reshape the world
New obesity treatments, including GLP-1 agonists and gene therapies, could make it easier for people to lose weight and keep it off.
One-shot gene therapy for liver disorder works in a small trial
A new gene therapy for the rare liver disorder Crigler-Najjar syndrome was highly effective in a small trial.
Extreme treatment for alcoholism slashes drinking by 90% in monkeys
An in-development treatment for alcoholism dramatically reduced consumption in monkeys that previously drank heavily.
Scientists make pain relievers like Tylenol from pine trees rather than fossil fuels
Chemists have shown how to manufacture ibuprofen and acetaminophen using a waste product from the forestry and paper industries.
Weight-loss drug cut the risk of heart attack and stroke by 20% in large trial
The weight-loss drug semaglutide reduced patients’ risk of heart attacks, strokes, or death from heart disease by 20% in a large trial.
Fragile X syndrome often results from improperly processed genetic material
Researchers discovered that the mutated gene responsible for fragile X syndrome is active in most people with the disorder, not silenced.
Study finds tracking brain waves could reduce post-op complications
Researchers found brain wave signatures that could help determine when patients are transitioning into a deep state of unconsciousness.
Targeted therapy kills every type of cancer in the lab
City of Hope researchers are trialing a targeted therapy shown to kill more than 70 types of cancer in preclinical tests.
Immune cells in the brain may reduce damage during seizures and promote recovery
Microglia perform many functions in the brain, and their role in seizures is unclear — a new study in mice aims to find out more.
First-of-their-kind eye drops reverse blindness in teen
A topical gene therapy designed to heal the wounds of people with “butterfly skin disease” has now been used to reverse blindness.
New RSV shot protects babies against dangerous lung infections
The FDA has approved nirsevimab, an RSV shot that protects babies against the leading cause of infant hospitalizations in the US.
ADHD drugs could alleviate symptoms of Alzheimer’s
Scientists reviewed 40 years of clinical studies that assessed the effects of NA-targeting drugs, such as certain ADHD drugs, on Alzheimer’s.
Radioactive drugs are transforming cancer treatment
Radiopharmaceuticals allow doctors to directly target patients' cancer cells and avoid healthy tissue typically damaged by radiation therapy.
Not all repellents are equal – here’s how to avoid mosquito bites this summer
Researchers studied different types of mosquito repellents and their efficacy for over a decade. Here's what they found.
A functional cure for brittle diabetes is now available in the US
Islet transplantation, a procedure shown to functionally cure some people with hard-to-control brittle diabetes, has been approved in the US.
Drug to grow new teeth heads to human trials
A drug that causes animals to grow new teeth could one day allow us to regenerate teeth lost to injury, disease, or old age.
Newly identified type of depression affects 27% of patients
Stanford University researchers have identified a new, hard-to-treat type of depression characterized by problems with cognition.
AI-developed drug for deadly lung disease reaches phase 2 trials
AI-driven drug development has led to the launch of phase 2 trials of a drug to treat idiopathic pulmonary fibrosis (IPF).
“Backdoor” into the ear offers new hope for reversing deafness
A new study has unlocked a “backdoor” into the inner ear that could make administering gene therapies to restore hearing less risky.
Certain diets can starve cancer cells
Low-calorie, intermittent-fasting, and ketogenic diets all can lower the amount of blood glucose available to fuel cancer cells.
A simple tweak could improve treatment of a deadly herpes brain infection
Anti-inflammatory drugs could potentially prevent herpes encephalitis from causing permanent brain damage.
Nasal drops might prevent PTSD
New research shows that nasal drops of neuropeptide Y triggers extinction of fear memories in an animal model of PTSD.
One shot epilepsy treatment reduced seizures by 95% in first two patients
A stem cell-based treatment for epilepsy slashed the number of seizures experienced by two trial participants by 95%.
Insulin grown in lettuce can be taken orally
New synthetic insulin harvested from lettuce plants can be made cheaply, taken orally, and transported at room temperature.
Cancer med appears to prevent brain aneurysms
Japanese researchers have discovered that the cancer drug sunitinib can prevent the formation of brain aneurysms in mice.
SpaceX successfully launches world’s first “space factory”
SpaceX has successfully deployed a “space factory” developed by startup Varda Space Industries to manufacture drugs in microgravity.
Cheap drug appears to cut long COVID risk by 41% in small study
The diabetes drug metformin cut COVID-19 patients’ risk of later developing long COVID by 41% in a small study.
90% of patients respond to new blood cancer treatment in trial
Israeli researchers have developed a new form of CAR-T therapy effective against multiple myeloma, a plasma cell cancer.
Made-to-fade tattoo ink keeps cancer therapy from leaving a mark
Henry Ford Health researchers are using temporary tattoo ink to help radiation therapy patients for whom permanent tattoos may not be an option.